The Third dose of CoronVac vaccination induces broad and potent adaptive immune responses that recognize SARS-CoV-2 Delta and Omicron variantsCoronVac 백신 3차 접종은 SARS-CoV-2 Delta 및 Omicron 변이체를 인식하는 광범위하고 강력한 적응 면역 반응 유도Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response B cell B cells boost booster booster dose booster vaccination CD4 CD8 Cell circulating comparable contagious CoronaVac coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Delta demonstrated detectable domain dose effective elevated elicited fold follicular healthy subject helper T cell Humoral immunity IgA responses immune responses Inactivated vaccine individual induce memory B memory B cell memory B cells neutralization neutralization activities neutralization activity neutralization. neutralizing activities omicron Omicron variants peaked predominant preserved Protein RBD receiving recognize reduced remained respiratory response SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 variant significantly increased spike-specific IgG strain subpopulations sustained T cell T cell responses T cells T cells response vaccination variant variants VOCs [DOI] 10.1080/22221751.2022.2081614 PMC 바로가기 [Article Type] Article
Antibody titers after a third dose of the SARS-CoV-2 BNT162b2 vaccine in immunocompromised adults in Greece: Is a fourth dose necessary?그리스의 면역 저하 성인에서 SARS-CoV-2 BNT162b2 백신 3차 접종 후 항체 역가: 4차 접종이 필요한가요?Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] age anti-S Anti-spike antibody Antibody titers Autoimmune autoimmune diabete autoimmune diabetes Autoimmune disease average baseline BNT162b2 BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine BNT162b2 vaccine change correlated COVID-19 Decline decrease diabetes dose Effectiveness fold Fold change Fold changes Greece humoral Humoral response IgG antibody titer IgG antibody titers IgG GMC Immunocompromised immunocompromised adult immunocompromised adults immunocompromised individual immunocompromised individuals immunogenicity Inflammatory inflammatory disease leukemia lymphoma mRNA of BNT162b2 Omicron variant Omicron variants postvaccination real-world data SARS-CoV-2 serum sample serum samples Sex significantly the SARS-CoV-2 the vaccine third dose. vaccination Vaccine vaccine dose vulnerable population [DOI] 10.1002/jmv.27954 PMC 바로가기 [Article Type] Article
On virus and nanomaterials – Lessons learned from the innate immune system – ACE activation in the invertebrate model Enchytraeus crypticus바이러스 및 나노물질에 관하여 - 선천적 면역계에서 배운 교훈 - 무척추동물 모델 Enchytraeus crypticus에서 ACE 활성화Article Published on 2022-08-152022-09-11 Journal: Journal of hazardous materials [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE ACE gene ACE2 Activation angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 caused Cell Community Conserved mechanisms Corona Corona virus COVID-19 current database develop down-regulation enzyme experiment expression fold functional immune immune system Inflammatory Innate innate immune response innate immune system invertebrate invertebrates knowledge lesson mechanism Nanomaterial nanomaterials Other receptor Research respiratory responses SARS-CoV-2 Severe acute respiratory syndrome Spike proteins stress condition stress conditions stress response Stress response. Support the spike protein therapy threat Threats Total transfer triggering vertebrates virus [DOI] 10.1016/j.jhazmat.2022.129173 PMC 바로가기 [Article Type] Article
Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infectionOmicron BA.4/BA.5 탈출 중화 면역 BA.1 감염Article Published on 2022-08-102022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] absence B.1.1.529 change Decline decrease elicited fold Immunity individuals infected individuals Infection lineages neutralization neutralizing immunity omicron Receptor binding domain SARS-CoV-2 selective South Africa Spike receptor binding domain subsequent Substitution substitutions the strongest vaccinated individual vaccinated individuals vaccination virus Virus neutralization viruses [DOI] 10.1038/s41467-022-32396-9 PMC 바로가기 [Article Type] Article
Exosomal Vaccine Loading T Cell Epitope Peptides of SARS-CoV-2 Induces Robust CD8 + T Cell Response in HLA-A Transgenic MiceSARS-CoV-2의 엑소좀 백신 로딩 T 세포 에피토프 펩티드는 HLA-A 형질전환 마우스에서 강력한 CD8 + T 세포 반응을 유도합니다Article Published on 2022-07-292022-09-11 Journal: International journal of nanomedicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adjuvant Administered CD8 control group Coronavirus-2 current elicited epitope epitope peptide Ex vivo exosomal vaccine Exosome Exosomes fold followed by fraction frequencies Frequency fused generate HLA-A human leukocyte antigen human leukocyte antigen-A IFN-γ induce injected intracellular cytokine staining leukocyte mice Modification Neutralizing antibodies neutralizing antibody NMR nuclear nuclear magnetic resonance organ toxicity peak peptide peptides purification purified response robust SARS-CoV-2 SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly subcutaneously T cell T cell response T cell responses T cells the SARS-CoV-2 virus the severe acute respiratory syndrome coronavirus-2. transgenic mice transmission electron microscopy Vaccine vaccine group western blotting wild-type [DOI] 10.2147/IJN.S367494 PMC 바로가기 [Article Type] Article
Identification of critical genes and molecular pathways in COVID-19 myocarditis and constructing gene regulatory networks by bioinformatic analysis코로나19 심근염의 핵심 유전자 및 분자경로 규명 및 생물정보분석을 통한 유전자 조절 네트워크 구축Article Published on 2022-06-242022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] adjusted Algorithms analysis Analysis bioinformatic analysis bioinformatics biological processe biological processes CDC20 CDK1 Cell cell cycle Compound correlation COVID-19 Critical Cytoscape dataset DEGs differentially expressed gene down-regulated genes drug drugs enrichment analysis etoposide Evidence evidence of fold Functional enrichment analyses Functional enrichment analysis Gene Expression Gene Expression Omnibus gene regulatory network Genes GEO highlighting hydrolysis identification identify in vitro indicated infected with SARS-CoV-2 Interaction KIF20A KIF2C mechanism methotrexate molecular myocarditis network analysis overlapped P-value Pathogenesis pathway Patient PBK performed Perspective pluripotent stem cell Potential biomarker potential biomarkers PPI probe protein-protein interaction provide R software Regulatory signature target transcription factor Treatment Troglitazone turquoise module UBE2C up-regulated was used website were assessed WGCNA with COVID-19 [DOI] 10.1371/journal.pone.0269386 PMC 바로가기 [Article Type] Article
Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants렘데시비르와 GS-441524는 델타, 오미크론 및 기타 신종 SARS-CoV-2 변이체에 대해 항바이러스 활성을 유지한다Article Published on 2022-06-212022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 50% effective concentration activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity Antiviral agents Antiviral treatment change circulating Combination conserved coronavirus COVID-19 Delta disease severity Effectiveness ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay Evidence evidence of exhibited fold Genetic variation GS-441524 highlight isolate Neutralizing antibodies Nsp12 nucleoside omicron Omicron variants Other P323L pandemic parent nucleoside potency predominant prevalent RdRP RDV reduction remained Remdesivir remdesivir. retained RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence sequences severe acute respiratory syndrome Coronavirus Spread Substitution Support susceptible sustained tested the SARS-CoV-2 Treatment Vaccine variant variants Variation Veklury Viral transmission virus viruses WA1 [DOI] 10.1128/aac.00222-22 PMC 바로가기 [Article Type] Article
Resistance of SARS-CoV-2 Omicron BA.1 and BA.2 Variants to Vaccine-Elicited Sera and Therapeutic Monoclonal AntibodiesSARS-CoV-2 Omicron BA.1 및 BA.2 변이체의 백신 유도 혈청 및 치료용 단일클론 항체에 대한 내성Article Published on 2022-06-182022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] AstraZeneca BNT162b2 BNT162b2 vaccine COVID-19 D614G Effectiveness Emergency use fold immunization individual Lilly LY-CoV555 mixture monoclonal monoclonal antibodies monoclonal antibody monoclonal antibody therapy mutated neutralized Neutralizing titer omicron Omicron BA.2 Omicron variants parental Regeneron REGN10933 REGN10987 remained resistance SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants severe COVID-19 significantly Spike protein spike protein. Spike proteins therapeutic therapy titer titers Vaccine variant variants virus [DOI] 10.3390/v14061334 PMC 바로가기 [Article Type] Article
Immune response of booster doses of BBIBP-CORV vaccines against the variants of concern of SARS-CoV-2SARS-CoV-2의 우려 변종에 대한 BBIBP-CORV 백신의 추가 용량의 면역 반응Observational Study Published on 2022-06-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] (alpha Alpha Antibody titer Antibody titers approved BBIBP-CorV Beta booster booster dose booster doses Cohort COVID-19 COVID-19 vaccination COVID-19 vaccinations dose doses Evidence fold immune response inactivated Inactivated vaccine Inactivated Vaccines inactive individual Lineage lineages neutralization test Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers neutralizing effect observational study offered plaque pooled serum primary dose primary doses PRNT recipient recipients reduction reduction in sample pool SARS-CoV-2 SARS-CoV-2 variants serum serum sample serum samples statistically significant Test the SARS-CoV-2 Vaccinations Vaccine vaccine cohort variant variants variants of concern variants of concern. was done Wuhan [DOI] 10.1016/j.jcv.2022.105161 PMC 바로가기 [Article Type] Observational Study
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccineSARS-CoV-2 mRNA 백신 3차 접종 후 오미크론 반응성 B 세포 기억의 효율적인 회수Article Published on 2022-05-262022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] added Alpha antibody Antibody titer Antibody titers Antigen B cell memory Beta booster Cell circulating antibodies circulating antibody correlated COVID-19 Delta dose efficient examined fold immune immune memory Immunity IMPROVE increase in limit memory B memory B cell memory B cells mRNA mRNA vaccination mRNA vaccine neutralizing antibody titers omicron Omicron variants quantity RBD-specific memory B cells recall remained response SARS-CoV-2 spike These data vaccination Vaccine variants variants of concern variants of concern. wild-type [DOI] 10.1016/j.cell.2022.04.009 PMC 바로가기 [Article Type] Article